Cat. No.: 535 003
Amount: 50 µg
Price:
$380.00
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| Cat. No. 535 003 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Synthetic peptide corresponding to residues surrounding AA 160 of mouse VNUT (UniProt Id: Q8VCL5) |
| Data sheet | 535_003.pdf |
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Vesicular nucleotide transporter (VNUT), also known as SLC17A9, is a member of the SLC17 phosphate transporter family, which also includes the vesicular glutamate transporters (VGLUTs). Similar to VGLUTs, VNUT is responsible for vesicular accumulation—specifically of ATP and other nucleotides (1).
Expression of VNUT has been observed in several secretory systems, including insulin-containing granules of pancreatic β-cells and GLP-1–positive vesicles of intestinal L cells (2–3). In the nervous system, VNUT-immunopositive neurons have been identified in the hypothalamic and hindbrain nuclei, suggesting a role in ATP-mediated purinergic signaling involved in the regulation of ovulation via activation of kisspeptin neurons (4). Additionally, VNUT is expressed in spinal dorsal horn neurons of the peripheral nervous system, where it mediates exocytotic ATP release and contributes to neuropathic pain mechanisms following peripheral nerve injury (5).